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Reversible Tacrolimus-Induced Neurotoxicity Isolated to the Brain Stem
AJNR 21:1251-1254, Oliverio,P.J. et al, 2000
See this aricle in Pubmed

Article Abstract
Diplopia, nystagmus, visual hallucinations, and internuclear ophthalmoplegia developed in a 30-year-old woman 84 days after she received a matched, unrelated bone marrow transplant for chronic myeloid leukemia. A regimen of tacrolimus had been administered since the transplantation was performed. MR imaging revealed bilaterally symmetric regions of signal abnormality with abnormal contrast enhancement in the brain stem. No supratentorial abnormality was present. Tacrolimus therapy was discontinued, and the symptoms resolved. MR imaging that was performed 10 days after tacrolimus was discontinued showed resolution of the abnormalities.
 
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adverse drug reaction
brainstem
brainstem,lesion of
chemotherapy,CNS treatment and complications with
gadolinium
immunosuppressive agents
internuclear ophthalmoplegia
midbrain,lesion of
MRI,abnormal
MRI,contrast enhanced
MRI,disappearing lesion on
MRI,FLAIR
neurotoxic
tacrolimus
transient neurologic deficit

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